[Withdrawal syndrome after the use of serotonin reuptake inhibitors]

Abstract

Background: The use of serotonin reuptake inhibitors in the treatment of depression has increased significantly over the years since their introduction in Norway in the early 1990s. Reports of side effects have paralleled the increased use; one side effect is the withdrawal syndrome associated with serotonin reuptake inhibitors.

Material and methods: This article reports on two patients who discontinued paroxetine and experienced unusual shock-like symptoms consistent with this syndrome.

Results: There are numerous reports documenting withdrawal reactions caused by these antidepressants. Recently the first controlled studies have been published.

Interpretation: This syndrome is not well known and differs from the withdrawal syndrome caused by tricyclic antidepressants.