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. 2000;2003(2):CD000109.
doi: 10.1002/14651858.CD000109.

Hormones for suspected impaired fetal growth

A M Gülmezoglu  1 , G J Hofmeyr
Affiliations

Hormones for suspected impaired fetal growth

A M Gülmezoglu et al. Cochrane Database Syst Rev. 2000.

Update in

Abstract

Background: It has been suggested that oestrogens may improve fetal growth due to an increase in nutritional supply to the fetus from greater uterine blood flow.

Objectives: The objective of this review was to assess the effects of hormone administration for suspected impaired fetal growth and perinatal outcome.

Search strategy: We searched the Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register. Date of last search: 22 December 1999.

Selection criteria: Acceptably controlled trials of hormone administration for suspected impaired fetal growth which report fetal, perinatal or maternal outcomes.

Data collection and analysis: Eligibility and trial quality were assessed.

Main results: No studies were included since none of the potentially relevant trials reported clinical outcomes.

Reviewer's conclusions: There is not enough evidence to evaluate the clinical use of hormone administration for suspected impaired fetal growth.

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Conflict of interest statement

None known.

References

References to studies excluded from this review

Grunberger 1981 {published data only}
    1. Grunberger W, Parschalk O, Fischl F. Treatment of hypotension complicating pregnancy improves fetal outcome. Medizinische Klinik 1981;76:257‐60. - PubMed
Niven 1974 {published data only}
    1. Niven PAR, Buhi WC, Spellacy WN. The effect of intravenous oestrogen injections on plasma human placental lactogen levels. Journal of Obstetrics and Gynaecology of the British Commonwealth 1974;81:466‐8. - PubMed
Pearce 1988 {published data only}
    1. Pearce JM, McParland P, Steel SA, Huiskes N. Effect of allyloestrenol on deteriorating uteroplacental circulation. Lancet 1988;2:1252. - PubMed
    1. Pearce JM, Steel SA. A double blind placebo controlled pilot study on the effects of allylestrenol on flow velocity wave forms from the uteroplacental and fetal circulation. World Congress of Gynecology and Obstetrics; 1988 October 23‐28; Brazil. 1988:249.
Thoumsin 1975 {published data only}
    1. Thoumsin H, Lambotte R. Therapeutic possibilities of dehydroepiandrosterone in foetal hypotrophy. Annales d' Endocrinologie (Paris) 1975;36:113‐4. - PubMed

Additional references

Bernstein 2000
    1. Bernstein IM, Horbar JD, Badger GJ, Ohlsson A, Golan A. Morbidity and mortality among very low birth weight infants with intrauterine growth restriction. The Vermont Oxford Network. American Journal of Obstetrics and Gynecology 2000;182:198. - PubMed
Clarke 2000
    1. Clarke M Oxman AD, editors. Cochrane Reviewers' Handbook 4.1 [updated June 2000]. In: Review Manager (RevMan) [Computer program]. Version 4.1 Oxford, England: The Cochrane Collaboration, 2000.
Greiss 1970
    1. Greiss FC, Anderson SG. Effect of ovarian hormones on the uterine vascular bed. American Journal of Obstetrics and Gynecology 1970;107:829. - PubMed
Killam 1973
    1. Killam AP, Rosenfeld CR, Battaglia FC, Makowski EL, Meschia G. Effect of estrogens on the uterine blood flow of oophorectomized ewes. American Journal of Obstetrics and Gynecology 1973;115:1045. - PubMed
Lin 1998
    1. Lin C, Santolaya‐Forgas J. Current concepts of fetal growth restriction: Part 1. Causes, classification, and pathophysiology. Obstetrics & Gynecology 1998;92(6):1044‐55. - PubMed
Resnik 2002
    1. Resnik R. Intrauterine growth restriction. Obstetrics & Gynecology 2002;99(3):490‐6. - PubMed

References to other published versions of this review

Gülmezoglu 2002
    1. Gülmezoglu AM, Hofmeyr GJ. Hormones for suspected impaired fetal growth. The Cochrane Library 2002, Issue 2. - PMC - PubMed

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