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. 2000:(2):CD000124.
doi: 10.1002/14651858.CD000124.

Lobeline for smoking cessation

L F Stead  1 , J R Hughes
Affiliations

Lobeline for smoking cessation

L F Stead et al. Cochrane Database Syst Rev. 2000.

Update in

  • Lobeline for smoking cessation.
    Stead LF, Hughes JR. Stead LF, et al. Cochrane Database Syst Rev. 2012 Feb 15;2012(2):CD000124. doi: 10.1002/14651858.CD000124.pub2. Cochrane Database Syst Rev. 2012. PMID: 22336780 Free PMC article.

Abstract

Background: Lobeline is a partial nicotine agonist, which has been used in a variety of commercially available preparations to help stop smoking.

Objectives: The objective of this review was to assess the effects of lobeline on long term smoking cessation.

Search strategy: We searched the Cochrane Tobacco Addiction Group trials register.

Selection criteria: Randomized trials comparing lobeline to placebo or an alternative therapeutic control, which reported smoking cessation with at least six months follow-up.

Data collection and analysis: We extracted data in duplicate on the type of subjects, the dose and form of lobeline, the outcome measures, method of randomisation, and completeness of follow-up.

Main results: We identified no trials meeting the full inclusion criteria including long term follow-up.

Reviewer's conclusions: There is no evidence available from long term trials that lobeline can aid smoking cessation.

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