Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Dec;20(6):729-35.
doi: 10.1007/BF01683593.

In vitro inhibition of digestive enzymes by heavy metals and their reversal by chelating agent: Part I. Mercuric chloride intoxication

K V Sastry, P K Gupta

In vitro inhibition of digestive enzymes by heavy metals and their reversal by chelating agent: Part I. Mercuric chloride intoxication

K V Sastry et al. Bull Environ Contam Toxicol. 1978 Dec.

Abstract

The effect of mercury on alkaline phosphatase, lipase, aminotripeptidase and glycylglycine dipeptidase in the liver and digestive tract of Channa punctatus is investigated in vitro. Mercury inhibits the activities of all these enzymes and the degree of inhibition increases with the increase in the concentration of the metal. Addition of EDTA, a chelating agent, restored the mercury inhibited enzyme activity and the degree of restoration was related to the concentration of the chelating agent.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Acta Pharmacol Toxicol (Copenh). 1973;33(5):449-58 - PubMed
    1. AMA Arch Ind Health. 1957 Jul;16(1):64-6 - PubMed
    1. Ind Med Surg. 1962 Jul;31:308-10 - PubMed
    1. Chem Biol Interact. 1976 May;13(2):181-92 - PubMed
    1. Pharmacol Rev. 1961 Jun;13:185-224 - PubMed