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. 2000 Jun 1;154(1):101-5.
doi: 10.1016/s0304-3835(00)00386-4.

Inhibitory effect of flavonoids from citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

Y Iwase  1 , Y Takemura, M Ju-ichi, C Ito, H Furukawa, S Kawaii, M Yano, X Y Mou, J Takayasu, H Tokuda, H Nishino
Affiliations

Inhibitory effect of flavonoids from citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

Y Iwase et al. Cancer Lett. .

Abstract

To search for possible anti-tumor promoters, thirteen flavones (1-13) obtained from the peel of Citrus plants were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these flavones, 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT) (13) exhibited significant inhibitory effects on the EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA). Further, compound 13 exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

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