Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Apr 29;355(9214):1518-9.
doi: 10.1016/S0140-6736(00)02169-3.

Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease

A Fasano, T Not, W Wang, S Uzzau, I Berti, A Tommasini, S E Goldblum

Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease

A Fasano et al. Lancet. .

Abstract

We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources