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. 1975 Aug;12(2):404-10.
doi: 10.1128/iai.12.2.404-410.1975.

Plasmid-linked ampicillin resistance in haempohilus influenza type b

L P Elwell, J De Graaff, D Seibert, S Falkow

Plasmid-linked ampicillin resistance in haempohilus influenza type b

L P Elwell et al. Infect Immun. 1975 Aug.

Abstract

Four ampicillin-resistant, beta-lactamase-producing strains of Haempohilus influenzae type b were examined for the presence of plasmid deoxyribonucleic acid (DNA). Three resistant strains contained a 30 x 10-6-dalton (30Mdal) plasmid and one resitant strain contained a 3-Mdal plasmid. The ampicillin-sensitive Haemophilus strains examined did not contain plasmid DNA. Transformation of a sensitive H. influenzae strain to ampicillin resistance with isolated plasmid DNA preparations revealed that the structural gene for beta-lactamase resided on both plasmid species. DNA-DNA hybridization studies showed that the 30-Mdal Haemophilus plasmid contained the ampicillin translocation DNA segment (TnA) found on some R-factors of enteric origin of the H. influenzae plasmids.

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References

    1. Antimicrob Agents Chemother. 1974 Jun;5(6):547-52 - PubMed
    1. Antimicrob Agents Chemother. 1974 Nov;6(5):625-9 - PubMed
    1. Mol Gen Genet. 1974;132(1):31-40 - PubMed
    1. J Bacteriol. 1973 Feb;113(2):772-80 - PubMed
    1. J Bacteriol. 1974 Feb;117(2):619-30 - PubMed

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