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Review
. 2000 Apr 20;10(8):R315-7.
doi: 10.1016/s0960-9822(00)00439-5.

How to activate p53

T Caspari  1
Affiliations
Free article
Review

How to activate p53

T Caspari. Curr Biol. .
Free article

Abstract

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

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