Review
doi: 10.1016/s0955-0674(00)00100-9.
Nuclear transport and transcription
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- PMID: 10801461
- DOI: 10.1016/s0955-0674(00)00100-9
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Review
Nuclear transport and transcription
Curr Opin Cell Biol.
2000 Jun.
Abstract
The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection between the nuclear transport machinery and the transcriptional apparatus. General transcription factors, as well as specific transcriptional activators and repressors, such as p53 and NF-AT, need to be imported into the nucleus following their translation. In addition, nuclear transport plays a crucial role in regulating the activity of many transcription factors.
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