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Review
. 2000 Jun;12(3):355-60.
doi: 10.1016/s0955-0674(00)00100-9.

Nuclear transport and transcription

A Komeili  1 , E K O'Shea
Affiliations
Review

Nuclear transport and transcription

A Komeili et al. Curr Opin Cell Biol. 2000 Jun.

Abstract

The compartmentalization of DNA in the nucleus of eukaryotic cells establishes a connection between the nuclear transport machinery and the transcriptional apparatus. General transcription factors, as well as specific transcriptional activators and repressors, such as p53 and NF-AT, need to be imported into the nucleus following their translation. In addition, nuclear transport plays a crucial role in regulating the activity of many transcription factors.

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