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Review
. 2000 May;7(5):R103-7.
doi: 10.1016/s1074-5521(00)00115-0.

Allosteric drugs: thinking outside the active-site box

B S DeDecker  1
Affiliations
Review

Allosteric drugs: thinking outside the active-site box

B S DeDecker. Chem Biol. 2000 May.

Abstract

Recently, a class of small molecules that thermally stabilize the tumor suppressor p53 was selected from a small-molecule library. This, and other recent work, demonstrates the feasibility of taking a lead from nature and selecting new classes of drugs that function by allosteric mechanisms.

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