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Clinical Trial
. 2000 Mar-Apr;23(2):82-5.
doi: 10.1097/00002826-200003000-00004.

The effect of amantadine on levodopa-induced dyskinesias in Parkinson's disease: a double-blind, placebo-controlled study

B J Snow  1 , L Macdonald, D Mcauley, W Wallis
Affiliations
Clinical Trial

The effect of amantadine on levodopa-induced dyskinesias in Parkinson's disease: a double-blind, placebo-controlled study

B J Snow et al. Clin Neuropharmacol. 2000 Mar-Apr.

Abstract

We performed a double-blind, placebo-controlled, crossover study to assess the effect of amantadine versus placebo on levodopa-induced dyskinesias in Parkinson's disease. We found a 24% reduction in the total dyskinesia score after amantadine administration (p = 0.004). This improvement was achieved without any influence on the severity of "on" period parkinsonism. The results confirm that amantadine reduces levodopa dyskinesias and support the hypothesis that dyskinesias can be reduced by blockade of excitatory pathways in the basal ganglia.

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