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Comparative Study
. 1978 Oct;34(1):42-5.

Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency

H A Simmonds, C F Potter, A Sahota, J S Cameron, D R Webster, D M Becroft
Comparative Study

Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency

H A Simmonds et al. Clin Exp Immunol. 1978 Oct.

Abstract

Orotic acid excretion was normal when tested by three methods in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. These results do not support the speculation, based on the oroticaciduria observed by others, that the immunodeficiency in these disorders results from the inhibition of pyrimidine biosynthesis. An alternative hypothesis is discussed.

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References

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    1. Clin Sci Mol Med. 1978 May;54(5):579-84 - PubMed
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