Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Aug;29(2):337-41.

Human T-lymphocyte rosette formation: inhibition by cytochalasin B

G Cohnen, K Fischer, G Brittinger

Human T-lymphocyte rosette formation: inhibition by cytochalasin B

G Cohnen et al. Immunology. 1975 Aug.

Abstract

The effects of cytochalasin B, colchicine and vinblastine on the rosette formation of human T lymphocytes with neuraminidase-treated human erythrocytes (nHRBC) and with sheep red blood cells (SRBC) have been studied. Pretreatment of the lymphocytes with cytochalasin B which affects microfilament action reversibly inhibits both nHRBC and SRBC rosette formation. Colchicine and vinblastine known to interact with microtubules causes no major reduction in rosette-forming cells. The results suggest that normally functioning microfilaments are necessary for nHRBC and SRBC rosetting, whereas microtubules are not essential for the blinding of the erythrocytes to the lymphocytes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Exp Cell Res. 1973 Apr;79(1):73-8 - PubMed
    1. J Immunol. 1973 Jul;111(1):85-90 - PubMed
    1. Acta Haematol. 1974;51(2):65-75 - PubMed
    1. J Cell Biol. 1967 Aug;34(2):525-33 - PubMed
    1. Nature. 1967 Jan 21;213(5073):261-4 - PubMed

LinkOut - more resources