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. 2000 May;47(5):641-3.

Glutamate uptake is decreased in platelets from Alzheimer's disease patients

C Ferrarese  1 , B Begni, C Canevari, C Zoia, R Piolti, M Frigo, I Appollonio, L Frattola
Affiliations
  • PMID: 10805335

Glutamate uptake is decreased in platelets from Alzheimer's disease patients

C Ferrarese et al. Ann Neurol. 2000 May.

Abstract

Because excitotoxicity may be involved in neurodegeneration in Alzheimer's disease, we investigated possible modifications of platelet glutamate uptake in AD patients. High-affinity glutamate uptake was studied in platelets from 35 Alzheimer's disease patients, 10 multi-infarct dementia patients, and 35 age-matched normal controls; it was decreased by 40% in platelets from Alzheimer's disease patients compared with controls and with multi-infarct dementia patients. Platelet glutamate uptake could be used as peripheral marker of glutamatergic involvement and as adjunctive diagnostic tool in Alzheimer's disease patients.

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