Review
doi: 10.1073/pnas.97.10.5013.
Sortase, a universal target for therapeutic agents against gram-positive bacteria?
Affiliations
- PMID: 10805759
- PMCID: PMC33977
- DOI: 10.1073/pnas.97.10.5013
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Review
Sortase, a universal target for therapeutic agents against gram-positive bacteria?
Proc Natl Acad Sci U S A.
.
No abstract available
Figures
Major types of surface proteins in Gram-positive bacteria. Protein A,
an immunoglobulin-binding protein, is covalently linked to the cell
wall and exposed on the cell surface. The amidase LytA is loosely
attached to choline (CH) residues decorating teichoic acid (TA) and
lipoteichoic acid (LTA) in Streptococcus pneumoniae (4).
The actin-polymerizing protein ActA of Listeria
monocytogenes is membrane-anchored and exposed to the medium
(7). The β-lactamase BlaZ encoded by the resistance plasmid PI258 of
Staphylococcus aureus is associated to the membrane and
partially released into the medium (8). InlB of L.
monocytogenes is loosely attached to LTA (5, 6). It is weakly
exposed on the cell surface.
Steps involved in the mechanism of covalent anchoring to the cell wall
(adapted from refs. and 14). MurNac, N-acetylmuramic
acid.
Comment on
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Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections.Proc Natl Acad Sci U S A. 2000 May 9;97(10):5510-5. doi: 10.1073/pnas.080520697. Proc Natl Acad Sci U S A. 2000. PMID: 10805806 Free PMC article.
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