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Review
. 2000 May 9;97(10):5013-5.
doi: 10.1073/pnas.97.10.5013.

Sortase, a universal target for therapeutic agents against gram-positive bacteria?

P Cossart  1 , R Jonquières
Affiliations
Review

Sortase, a universal target for therapeutic agents against gram-positive bacteria?

P Cossart et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Major types of surface proteins in Gram-positive bacteria. Protein A, an immunoglobulin-binding protein, is covalently linked to the cell wall and exposed on the cell surface. The amidase LytA is loosely attached to choline (CH) residues decorating teichoic acid (TA) and lipoteichoic acid (LTA) in Streptococcus pneumoniae (4). The actin-polymerizing protein ActA of Listeria monocytogenes is membrane-anchored and exposed to the medium (7). The β-lactamase BlaZ encoded by the resistance plasmid PI258 of Staphylococcus aureus is associated to the membrane and partially released into the medium (8). InlB of L. monocytogenes is loosely attached to LTA (5, 6). It is weakly exposed on the cell surface.
Figure 2
Figure 2
Steps involved in the mechanism of covalent anchoring to the cell wall (adapted from refs. and 14). MurNac, N-acetylmuramic acid.
See this image and copyright information in PMC

Comment on

References

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