Theory of the relation between human brain activity (MEG) and hand movements

Abstract

Earlier research established that spontaneous changes in human sensorimotor coordination are accompanied by qualitative changes in the spatiotemporal dynamics of neural activity measured by multisensor electroencephalography and magnetoencephalography. More recent research has demonstrated that a robust relation exists between brain activity and the movement profile produced. In particular, brain activity has been shown to correlate strongly with movement velocity independent of movement direction and mode of coordination. Using a recently developed field theoretical model of large-scale brain activity itself based on neuroanatomical and neurophysiological constraints we show here how these experimental findings relate to the field theory and how it is possible to reconstruct the movement profile via spatial and temporal integration of the brain signal. There is a unique relation between the quantities in the theory and the experimental data, and fit between the shape of the measured and the reconstructed time series for the movement is remarkably good given that there are no free parameters.