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. 1975 Jul;32(1):34-41.
doi: 10.1038/bjc.1975.131.

Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma

M F Woodruff, N Dunbar
Free PMC article

Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma

M F Woodruff et al. Br J Cancer. 1975 Jul.
Free PMC article

Abstract

Local injection (i.e. injection at the site of tumour inoculation) of strains of C. Parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact CBA mice but has little or no effect on subcutaneous transplants of the same tumour in T-cell deprived mice. The anti-tumour effect of local injection of C. parvum, unlike that of systemic injection in this particular tumour system, thus appears to be T-cell dependent.

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