Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000:465:293-301.
doi: 10.1007/0-306-46817-4_25.

Design and testing of ribozymes for cancer gene therapy

J S Norris  1 , B Hoel, D Voeks, F Maggouta, M Dahm, W Pan, G Clawson
Affiliations
Review

Design and testing of ribozymes for cancer gene therapy

J S Norris et al. Adv Exp Med Biol. 2000.

Abstract

This chapter describes procedural aspects for development of ribozymes in general, and specifically, that cleave mRNA to an essential cellular gene, the AC40 subunit of RNA pol I. Ribozyme design includes functional selection of binding sites followed by computer modeling. These ribozymes are being used in vectors that target expression to the prostate via tissue specific promoters (Voeks, Norris, and Clawson, 1998) and have demonstrated efficacy.

PubMed Disclaimer

Publication types

LinkOut - more resources