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. 1975;49(6):734-42.
doi: 10.1159/000231457.

Rosette formation with mouse erythrocytes: probable marker for human B lymphocytes

S Gupta, M H Grieco

Rosette formation with mouse erythrocytes: probable marker for human B lymphocytes

S Gupta et al. Int Arch Allergy Appl Immunol. 1975.

Abstract

Studies of peripheral blood lymphocytes were performed in 10 healthy control subjects and 15 patients with hematological disorders. Spontaneous formation of mouse red blood cell-forming rosettes (MRFC) were observed with 8.1% of lymphocytes in control subjects (range 4.2--12.0%), while rosette formation with sheep red blood cells (SRFC) and complement-coated sheep erythrocyte (EAC rosettes) was present in 69.2 and 10.7%, respectively. Mouse rosette-forming cells were increased in parallel fashion with EAC rosettes in five patients with chronic lymphocytic leukemia suggesting that mouse red blood cells (MRBC) may serve as a B cell marker. A single patient with a lymphoma associated with increased peripheral SRFC did not have a concomitant rise of MRFC. It appears likely that MRBC will provide another detection marker for B lymphocytes by spontaneous rosette formation.

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