Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 May 15;149(4):761-6.
doi: 10.1083/jcb.149.4.761.

EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

J S Tirnauer  1 , B E Bierer
Affiliations
Review

EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

J S Tirnauer et al. J Cell Biol. .
No abstract available

PubMed Disclaimer

Figures

Figure 2
Figure 2
Models for microtubule tip localization. A protein specifically localized to the ends of growing microtubules could bind to tubulin heterodimers and copolymerize into the microtubule (A), or recognize a specific conformation at the growing microtubule end, such as the GTP cap or the unrolled sheet (B). Dissociation from the microtubule could result from exclusion as the protofilament seam closes or from the tension caused by seam closure.
Figure 3
Figure 3
The first step of the spindle orientation process in budding yeast. Microtubule binding proteins and cortical proteins are required. In the example shown, at the microtubule tip, Bim1p both increases microtubule dynamicity (arrows) and binds Kar9p at the cortex, followed by depolymerization (Lee et al. 2000; Korinek et al. 2000). In the subsequent step, the spindle is pulled (and pushed) into the bud neck through dynein-dependent forces.
See this image and copyright information in PMC

References

    1. Adames N.R., Cooper J.A. Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae . J. Cell Biol. 2000;149:863–874. - PMC - PubMed
    1. Askham J.M., Moncur P., Markham A.F., Morrison E.E. Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene. 2000;19:1950–1958. - PubMed
    1. Barker N., Morin P.J., Clevers H. The Yin-Yang of TCF/beta-catenin signaling. Adv. Cancer Res. 2000;77:1–24. - PubMed
    1. Beinhauer J.D., Hagan I.M., Hegemann J.H., Fleig U. Mal3, the fission yeast homolog of the human APC-interacting protein EB-1, is required for microtubule integrity and the maintenance of cell form. J. Cell Biol. 1997;139:717–728. - PMC - PubMed
    1. Benson D.A., Karsch-Mizrachi I., Lipman D.J., Ostell J., Rapp B.A., Wheeler D.L. GenBank. Nucl. Acids Res. 2000;28:15–18. - PMC - PubMed

Publication types

Substances