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Review
. 2000 May;105(10):1335-7.
doi: 10.1172/JCI10078.

The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family

Affiliations
Review

The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family

G P Kaushal et al. J Clin Invest. 2000 May.
No abstract available

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Figures

Figure 1
Figure 1
Comparison of domain structures of ADAMTSs, ADAMs and SVMPs. The first three boxes of each bar represent, respectively, the common prodomain and the metalloprotease and disintegrin domains present in all of the members of adamalysin family. ADAMTSs also possess a thrombospondin domain but lack the cysteine-rich, EGF-like, transmembrane, and cytoplasmic domains found in ADAMs. SVMPs and ADAMTSs do not contain transmembrane domains and are therefore secreted, whereas ADAMs are transmembrane proteins that localize to the cell surface.

Comment on

References

    1. Stone AL, Kroeger M, Xiang Q, Sang A. Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins (review) J Protein Chem. 1999;18:447–465. - PubMed
    1. Blobel CP. Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNFα and notch. Cell. 1997;90:589–592. - PubMed
    1. Black RA, White JM. ADAMs: focus on the protease domain. Curr Opin Cell Biol. 1998;10:654–669. - PubMed
    1. Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Genet. 2000;16:83–87. - PubMed
    1. Almeida EAC, et al. Mouse egg integrin α6β1 functions as a sperm receptor. Cell. 1995;81:1095–1104. - PubMed

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