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Comment
. 2000 May 23;97(11):5696-8.
doi: 10.1073/pnas.120178897.

Functional brain imaging to identify affected subjects genetically at risk for Alzheimer's disease

S I Rapoport  1
Affiliations
Comment

Functional brain imaging to identify affected subjects genetically at risk for Alzheimer's disease

S I Rapoport. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
rCBF responses in primary (striate) and association visual cortical areas, measured with PET and H215O during patterned flash stimulation at different frequencies, in control subjects and in Alzheimer's disease patients with mild dementia or moderate-severe dementia. Scaled increment in blood flow, ΔrCBF, corrects for global flow difference between groups. *, P < 0.05; **, P < 0.01, differs significantly from control mean. Coordinates (in millimeters) are in stereotactic (Talairach) space. Passive “parametric” stimulus paradigms such as this might be used to examine synaptic integrity in at-risk subjects, as well as drug effects on synaptic transmission in relation to dementia severity (see text). Modified from ref. . (The American Journal of Psychiatry 155, 785–794, 1998. Copyright 1998, the American Psychiatric Association. Reprinted by permission.)
See this image and copyright information in PMC

Comment on

  • Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.
    Small GW, Ercoli LM, Silverman DH, Huang SC, Komo S, Bookheimer SY, Lavretsky H, Miller K, Siddarth P, Rasgon NL, Mazziotta JC, Saxena S, Wu HM, Mega MS, Cummings JL, Saunders AM, Pericak-Vance MA, Roses AD, Barrio JR, Phelps ME. Small GW, et al. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6037-42. doi: 10.1073/pnas.090106797. Proc Natl Acad Sci U S A. 2000. PMID: 10811879 Free PMC article.

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