Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2000 May 2;162(9):1281-4.

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke

M D Hill  1 , P A Barber, J Takahashi, A M Demchuk, T E Feasby, A M Buchan
Affiliations
Case Reports

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke

M D Hill et al. CMAJ. .

Abstract

Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.

PubMed Disclaimer

Comment in

References

    1. J Am Coll Cardiol. 1987 Sep;10(3):627-32 - PubMed
    1. J Am Coll Cardiol. 1987 Jun;9(6):1205-13 - PubMed
    1. Br Heart J. 1990 Sep;64(3):177-81 - PubMed
    1. Thromb Haemost. 1990 Oct 22;64(2):276-80 - PubMed
    1. Br J Haematol. 1991 Apr;77(4):562-3 - PubMed

Publication types

MeSH terms

Substances