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. 2000 Feb 24;2(4):519-21.
doi: 10.1021/ol990409x.

A novel synthesis of 2-aryl-2H-indazoles via a palladium-catalyzed intramolecular amination reaction

J J Song  1 , N K Yee
Affiliations

A novel synthesis of 2-aryl-2H-indazoles via a palladium-catalyzed intramolecular amination reaction

J J Song et al. Org Lett. .

Abstract

[reaction: see text] A variety of 2-aryl-2H-indazoles were synthesized by the palladium-catalyzed intramolecular amination of the corresponding N-aryl-N(o-bromobenzyl)hydrazines. Of several sets of reaction conditions surveyed, the combination of Pd(OAc)2/dppf/tBuONa gave the best results. This method applies to a wide scope of substrates containing electron-donating and electron-withdrawing substituents.

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