An enantioconvergent route to (-)-shikimic acid via a palladium-mediated elimination reaction

Abstract

[reaction--see text] (-)-Shikimic acid, the key intermediate in the shikimate pathway in plants and microorganisms, has been synthesized in an enantioconvergent manner from both enantiomeric starting materials by employing a palladium-mediated elimination reaction as the key step.