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. 2000 Jul 1;106(1-2):220-7.
doi: 10.1016/s0165-5728(00)00202-2.

Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis

O H Kantarci  1 , E J Atkinson, D D Hebrink, C T McMurray, B G Weinshenker
Affiliations

Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis

O H Kantarci et al. J Neuroimmunol. .

Abstract

We studied the putative association of a C-->T polymorphism in exon-5 of IL-1beta and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically-matched controls were analyzed. There was no association between either polymorphism and disease susceptibility. Allele-2 of IL-1beta and allele-3 of the IL-1ra polymorphisms were associated with a favorable outcome (P=0.023 and P=0.030).

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