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. 2000 May;21(5):869-74.

Multiple sclerosis: comparison of trace apparent diffusion coefficients with MR enhancement pattern of lesions

S Roychowdhury  1 , J A Maldjian, R I Grossman
Affiliations

Multiple sclerosis: comparison of trace apparent diffusion coefficients with MR enhancement pattern of lesions

S Roychowdhury et al. AJNR Am J Neuroradiol. 2000 May.

Abstract

Background and purpose: Diffusion-weighted MR imaging and the trace apparent diffusion coefficient (ADC) provide important structural information about tissues. The purpose of this study was to investigate the relationship between trace ADC values and the enhancement pattern of multiple sclerosis (MS) lesions.

Methods: Ninety-six lesions, identified in 24 patients with MS, were characterized by their enhancement pattern on contrast-enhanced T1-weighted MR images. There were 57 nonenhancing lesions (NELs), 28 homogeneously enhancing lesions (HELs), and 11 ring-enhancing lesions (RELs). The trace ADC means for each type of lesion and for normal-appearing white matter (NAWM) were calculated and compared using Student's t-test.

Results: The mean trace ADC values for HELs (mean, 7.7 x 1(-10) m2s(-1); SD, 1.4 x 10(-10) m2s(-1)) were less than those for RELs (mean, 1.2 x 10(-9) m2s(-1); SD, 3.5 x 10(-10)m2s(-1)) and NELs (mean, 1.3 x 10(-9) m2(s-1); SD, 2.6 x 10(-10) m2(s-1)). There was a significant difference between the mean trace ADC values of HELs and RELs as well as between those for HELs and NELs. There was also a significant difference in the mean trace ADC values between all lesion types and NAWM (mean, 6.9 x 10(-10) m2s(-1); SD, 5.0 x 10(-11) m2s(-1)).

Conclusion: We found a predictable relationship between mean trace ADC and the pattern of enhancement in MS lesions, corresponding to reported histopathologic differences in myelination between lesion types and magnetization transfer ratios.

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Figures

<sc>fig</sc> 1.
fig 1.
Examples of an NEL and an REL in a patient with MS. A–D, Axial T2-weighted image (4000/110/1) (A), contrast-enhanced T1-weighted image (500/20/1) (B), isotropic diffusion-weighted image (4000/125/1) (C), and trace ADC map (D) show a T1-weighted NEL (arrow) and a T1-weighted REL (arrowhead). Both lesions show increased diffusion on the trace ADC map.
<sc>fig</sc> 2.
fig 2.
Example of an HEL in a patient with MS. A–D, Axial T2-weighted image (4000/110/1) (A), contrast-enhanced T1-weighted image (500/20/1) (B), isotropic diffusion-weighted image (4000/125/1) (C), and trace ADC map (D) show a T1-weighted HEL (arrow), which shows increased diffusion on the trace ADC map.
See this image and copyright information in PMC

References

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