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Comparative Study
. 1976 Jan 1;143(1):85-99.
doi: 10.1084/jem.143.1.85.

Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity

B Chesebro, K Wehrly
Comparative Study

Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity

B Chesebro et al. J Exp Med. .

Abstract

Congenic mouse strains differing only at genes within the H-2 complex were found to have virus-specific cytotoxic effector cells in their spleens during or after recovery from Friend leukemia virus-induced splenomegaly. These effector cells were theta-positive T lymphocytes which functioned in vitro without help or inhibition by B lymphocytes or glass-adherent cells. The antigenic specificities recognized by the effector cells were viral-induced cellular antigens apparently different from those identified by serological techniques.

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