Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Jun;231(6):919-26.
doi: 10.1097/00000658-200006000-00017.

Functional outcomes after ileal pouch-anal anastomosis for chronic ulcerative colitis

R Farouk  1 , J H Pemberton, B G Wolff, R R Dozois, S Browning, D Larson
Affiliations

Functional outcomes after ileal pouch-anal anastomosis for chronic ulcerative colitis

R Farouk et al. Ann Surg. 2000 Jun.

Abstract

Objective: To assess long-term outcomes after ileal pouch-anal anastomosis (IPAA) for chronic ulcerative colitis (CUC) with specific emphasis on patient sex, childbirth, and age.

Summary background data: Childbirth and the process of aging affect pelvic floor and anal sphincter function independently. Early function after IPAA is good for most patients. Nonetheless, there are concerns about the impact of the aging process as well as pregnancy on long-term functional outcomes after IPAA.

Methods: Functional outcomes using a standardized questionnaire were prospectively assessed for each patient on an annual basis.

Results: Of the 1,454 patients who underwent IPAA for CUC between 1981 and 1994, 1,386 were part of this study. Median age was 32 years. Median length of follow-up was 8 years. Pelvic sepsis was the primary cause of pouch failure irrespective of sex or age. Functional outcomes were comparable between men and women. Eighty-five women who became pregnant after IPAA had pouch function, which was comparable with women who did not have a child. Daytime and nocturnal incontinence affected older patients more frequently than younger ones. Incontinence became more common the longer the follow-up in older patients, but this was not found in younger patients. Poor anal function led to pouch excision in only 3 of 204 older patients.

Conclusions: Incontinence rates were significantly higher in older patients after IPAA for CUC compared with younger patients. However, this did not contribute to a greater risk of pouch failure in these older patients. Patient sex and uncomplicated childbirth did not affect long-term functional outcomes.

PubMed Disclaimer

Figures

None
Figure 1. Probability of no pouchitis: older patients versus younger patients.
None
Figure 2. Probability of no pouchitis: men versus women.
None
Figure 3. Probability of success: older patients versus younger patients.
None
Figure 4. Probability of success: men versus women.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Pemberton JH, Kelly KA, Beart RW, et al. Ileal pouch anal anastomosis for chronic ulcerative colitis. Long-term results. Ann Surg 1987; 206:504–511. - PMC - PubMed
    1. Michelassi F, Stella M, Block GE. Prospective assessment of functional results after ileal J pouch-anal restorative proctocolectomy. Arch Surg 1993; 128:889–894. - PubMed
    1. Fazio VW, Ziv Y, Church J, et al. Ileal pouch-anal anastomosis: complications and function in 1005 patients. Ann Surg 1995; 222:120–127. - PMC - PubMed
    1. Bannister JJ, Abouzekry L, Read NW. Effect of aging on anorectal function. Gut 1987; 29:353–357. - PMC - PubMed
    1. Lauberg S, Swash M. Effects of aging on the anorectal sphincters and their innervation. Dis Colon Rectum 1989; 32:737–742. - PubMed