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. 2000 Jun;44(6):1716-9.
doi: 10.1128/AAC.44.6.1716-1719.2000.

In vitro activities of membrane-active peptides alone and in combination with clinically used antimicrobial agents against Stenotrophomonas maltophilia

A Giacometti  1 , O Cirioni, M S Del Prete, F Barchiesi, M Fortuna, D Drenaggi, G Scalise
Affiliations

In vitro activities of membrane-active peptides alone and in combination with clinically used antimicrobial agents against Stenotrophomonas maltophilia

A Giacometti et al. Antimicrob Agents Chemother. 2000 Jun.

Abstract

The in vitro activities of buforin II, cecropin P1, and magainin II, alone and in combination with six clinically used antimicrobial agents, against 12 clinical isolates of Stenotrophomonas maltophilia were investigated. Antimicrobial activities were measured by MIC and time-kill studies. The isolates were susceptible to the peptides at concentrations in the range of 0.50 to 16 microg/ml. Synergy was observed when the peptides were combined with polymyxin E, meropenem, ceftazidime, piperacillin, and clarithromycin.

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Figures

FIG. 1
FIG. 1
Time-kill kinetics of membrane-active peptides against S. maltophilia SM-02.95 and S. maltophilia SM-01.98. Peptides were tested at concentrations of four times the MIC: buforin II, 4 (a) and 64 (b) μg/ml; cecropin P1, 8 (a) and 64 (b) μg/ml; and magainin II, 4 (a) and 64 (b) μg/ml.
See this image and copyright information in PMC

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