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. 2000 Jun;44(6):1728-30.
doi: 10.1128/AAC.44.6.1728-1730.2000.

Efficacy of FK463, a (1,3)-beta-D-glucan synthase inhibitor, in disseminated azole-resistant candida albicans infection in mice

S Maesaki  1 , M A Hossain, Y Miyazaki, K Tomono, T Tashiro, S Kohno
Affiliations

Efficacy of FK463, a (1,3)-beta-D-glucan synthase inhibitor, in disseminated azole-resistant candida albicans infection in mice

S Maesaki et al. Antimicrob Agents Chemother. 2000 Jun.

Abstract

The efficacy of FK463, a new (1,3)-beta-D-glucan synthase inhibitor, against azole-resistant Candida albicans strains has been studied. The MIC of FK463 was lower than those of azoles and amphotericin B against CDR1-expressing C26 and CaMDR-expressing C40 strains. All mice treated with FK463 (1 mg/kg) survived disseminated murine candidiasis. The fungal burden in the kidney after 6 days was markedly reduced after therapy with FK463 and amphotericin B sodium deoxycholate, and plasma (1,3)-beta-D-glucan concentration was found to be lower in FK463-treated mice. In our study, FK463 was found to be a potent antifungal agent against disseminated infection with azole-resistant C. albicans.

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Figures

FIG. 1
FIG. 1
Survival rate of mice with experimental disseminated candidiasis infected with CDR1-expressing (C26) (A) and CaMDR-expressing (C40) (B) azole-resistant C. albicans treated with 5% dextrose (filled circle), Fungizone (D-AmB) (1 mg/kg) (filled square), and FK463 (1 mg/kg) (open circle). Treatment started 2 h after inoculation. Different groups of mice were treated with FK463 or D-AmB intravenously for 5 days. Ten mice were included in each group (P < 0.05 for FK463 and D-AmB compared with 5% dextrose by generalized Wilcoxon test).
See this image and copyright information in PMC

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