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. 2000 Apr;39(4):377-81.
doi: 10.1093/rheumatology/39.4.377.

Linkage analysis of chromosome 2q in osteoarthritis

J Loughlin  1 , Z Mustafa, A Smith, C Irven, A J Carr, K Clipsham, J Chitnavis, V A Bloomfield, M McCartney, O Cox, J S Sinsheimer, B Sykes, K E Chapman
Affiliations

Linkage analysis of chromosome 2q in osteoarthritis

J Loughlin et al. Rheumatology (Oxford). 2000 Apr.

Abstract

Background: In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA).

Objective: To test chromosome 2q for linkage to idiopathic osteoarthritis.

Methods: Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage disease (ascertained by hip or knee joint replacement surgery), we conducted a linkage analysis of chromosome 2q using 16 polymorphic microsatellite markers at an average spacing of one marker every 8.5 cM.

Results: Our results provide suggestive evidence for a locus at 2q31 with a maximum multipoint logarithm of the odds score (MLS) of 1.22 which increased to 2.19 in those families concordant for hip-only disease (n = 311). This suggestive linkage was greater in male-hip families (MLS = 1.57, n = 71) than in female-hip families (MLS = 0.71, n = 132).

Conclusions: Chromosome 2q is likely to contain at least one susceptibility locus for OA.

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