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. 1975 Apr;20(1):65-71.

The relationship of autoantibodies to depression of cell-mediated immunity in infectious mononucleosis

A S Russell, J S Percy, M Grace

The relationship of autoantibodies to depression of cell-mediated immunity in infectious mononucleosis

A S Russell et al. Clin Exp Immunol. 1975 Apr.

Abstract

It has been postulated that autoantibody formation occurs as a consequence of a depression of function of certain thymus-derived lymphocytes (T cells). We have examined cell-mediated immunity, a T-cell function, in infectious mononucleosis, a condition in which autoantibodies are known to develop. We have shown some evidence of depressed cell-mediated immunity in patients with infectious mononucleosis but have been unable to correlate this with autoantibody production. These results do not support the hypothesis that depression of T-cell function leads to autoantibody formation.

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