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. 1975 Dec;72(12):5095-8.
doi: 10.1073/pnas.72.12.5095.

H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice

J F Miller, M A Vadas, A Whitelaw, J Gamble

H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice

J F Miller et al. Proc Natl Acad Sci U S A. 1975 Dec.

Abstract

Sensitized lymphocytes can transfer a state of delayed-type hypersensitivity to soluble protein antigens to naive mice only if donor and recipient share the I-A region of the H-2 gene complex. Identity at the K or D region is not essential. The restriction is unlikely to result from ineffective homing of the injected cells or from their early destruction. It is thought to reflect a requirement for an Ir-gene controlled mechanism which governs effective interaction between sensitized T lymphocytes and antigen presented on the surface of macrophages.

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References

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