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Case Reports
. 2000 Apr;84(4):505-7.
doi: 10.1093/oxfordjournals.bja.a013479.

Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment

A Patel  1 , E Harrison, A Durward, I A Murdoch
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Free article
Case Reports

Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment

A Patel et al. Br J Anaesth. 2000 Apr.
Free article

Abstract

Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administration of rhDNase to a 3-yr-old boy with acute life-threatening asthma in whom 48 h of aggressive therapy had failed.

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