Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1975;52(1):69-73.

Controlled field trial of a typhoid vaccine prepared with a nonmotile mutant of Salmonella typhi Ty2

M H Wahdan, J E Sippel, I A Mikhail, A E Rahka, E S Anderson, H A Sparks, B Cvjetanović
Clinical Trial

Controlled field trial of a typhoid vaccine prepared with a nonmotile mutant of Salmonella typhi Ty2

M H Wahdan et al. Bull World Health Organ. 1975.

Abstract

A controlled field trial was performed in Egypt to evaluate a whole cell typhoid vaccine prepared with a nonmotile mutant of S. typhi Ty2 (TNM1) devoid of flagellar antigen. This vaccine did not elicit an H antibody response, but significant Vi and O agglutinin responses were observed. There were 34 typhoid cases among 21 063 six- to seven-year-old children who received the TNM1 vaccine, and 44 cases among 21 017 children in the control group who received tetanus toxoid. These results suggest that TNM1 vaccine does not provide protection against typhoid fever, and that H antigen may be an important component of an effective vaccine.

PubMed Disclaimer

References

    1. Lancet. 1964 Dec 5;2(7371):1196-200 - PubMed
    1. Bull World Health Organ. 1964;31:761-91 - PubMed
    1. Bull World Health Organ. 1965;32:29-36 - PubMed
    1. Bull World Health Organ. 1964;30:653-62 - PubMed
    1. Bull World Health Organ. 1966;34(3):321-39 - PubMed

Publication types

Substances

LinkOut - more resources