Comment
doi: 10.1073/pnas.97.11.5687.
New paradigm for drug therapies of cardiac fibrillation
Affiliations
- PMID: 10823928
- PMCID: PMC33988
- DOI: 10.1073/pnas.97.11.5687
Item in Clipboard
Comment
New paradigm for drug therapies of cardiac fibrillation
Proc Natl Acad Sci U S A.
.
No abstract available
Figures
Illustration of wave breaks occurring by two fundamentally distinct
mechanisms: fixed heterogeneity corresponding to dispersion of
refractoriness (Left) and restitution-driven dynamic
heterogeneity (Right). (Left) Three
snapshots of a computer simulation of the cellular automaton model of
Moe et al. (10) on a 2.4-cm × 2.4-cm square tissue
made up of 60 × 60 square patches that are each 4 mm × 4
mm. Refractory periods vary randomly from patch to patch following the
rules prescribed in ref. . Green (black) squares correspond to
excitable (refractory) tissue and red squares correspond to the
activation wave front (i.e., squares that were just excited). Ten
successive stimuli were applied at the left-hand bottom corner of the
tissue and time increases from top to bottom. (Right)
Three snapshots of a computer simulation of a two-variable partial
differential equation ionic model that incorporates restitution (3),
for a 3.4-cm × 3.4-cm spatially homogeneous tissue without any
fixed heterogeneity. Time increases from top to bottom with the middle
and bottom frames being closely spaced in time. The transmembrane
voltage for the right column is color coded according to the right
bottom scale from −85 mV to +20 mV.
Comment on
-
Preventing ventricular fibrillation by flattening cardiac restitution.Proc Natl Acad Sci U S A. 2000 May 23;97(11):6061-6. doi: 10.1073/pnas.090492697. Proc Natl Acad Sci U S A. 2000. PMID: 10811880 Free PMC article.