Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Mar 1;143(3):684-9.
doi: 10.1084/jem.143.3.684.

Evidence for direct linkage between antigen recognition and lytic expression in effector T cells

R C Kuppers, C S Henney

Evidence for direct linkage between antigen recognition and lytic expression in effector T cells

R C Kuppers et al. J Exp Med. .

Abstract

The relationship between antigen recognition and lytic expression by effector T cells was examined by coculturing two cytolytically active lymphoid cell populations. When antigen recognition between the populations could occur only in one direction, then cytotoxicity was expressed only in that direction and the population whose antigens were recognized lost its lytic activity. In contrast, the cocultured effector cell population fully maintained its lytic potential. This lack of reciprocal inactivation was taken as evidence that T-cell receptor accomodation by surface antigen is linked to the expression of cytolytic activity by effector T lymphocytes.

PubMed Disclaimer

References

    1. J Immunol Methods. 1974 Mar;4(2):301-15 - PubMed
    1. J Exp Med. 1971 Dec 1;134(6):1385-402 - PubMed
    1. Adv Immunol. 1969;11:117-93 - PubMed
    1. Immunology. 1968 Feb;14(2):181-96 - PubMed
    1. J Immunol. 1975 Dec;115(6):1592-8 - PubMed

Publication types