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Review
. 2000 Jun;21(6):273-80.
doi: 10.1016/s0167-5699(00)01629-7.

Interleukin 16: implications for CD4 functions and HIV-1 progression

D M Center  1 , H Kornfeld, T C Ryan, W W Cruikshank
Affiliations
Free article
Review

Interleukin 16: implications for CD4 functions and HIV-1 progression

D M Center et al. Immunol Today. 2000 Jun.
Free article

Abstract

In this article, David Center and colleagues clarify the controversies that have emerged over the unique structure of interleukin 16 and its anti-HIV-1 activity. Interleukin 16 is a ligand for CD4, and this implies CD4 acts as a sentinel receptor that can switch CD4+ T cells between immune and inflammatory functions.

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