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Review
. 2000 Jun;10(3):257-61.
doi: 10.1016/s0959-437x(00)00085-x.

Left-right axis malformations in man and mouse

B Casey  1 , B P Hackett
Affiliations
Review

Left-right axis malformations in man and mouse

B Casey et al. Curr Opin Genet Dev. 2000 Jun.

Abstract

The study of left-right axis malformations in man and mouse has greatly advanced understanding of the mechanisms regulating vertebrate left-right axis formation. Recently, the roles of the TGF-beta family, Sonic hedgehog and fibroblast growth factor signaling, homeobox genes, and cilia in left-right axis determination have been more clearly defined. The identification of genes and environmental factors affecting left-right axis formation has important implications for understanding human laterality defects.

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