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. 1976 Jan-Feb;39(1):31-5.

[Influence of substances that change the serotonin level of the brain on the analgesic effect of promedol in rats]

[Article in Russian]
L K Murakhina
  • PMID: 1082823

[Influence of substances that change the serotonin level of the brain on the analgesic effect of promedol in rats]

[Article in Russian]
L K Murakhina. Farmakol Toksikol. 1976 Jan-Feb.

Abstract

In tests with determination of pain reaction in rats registered by their squeak and arising in reponse to a single electric irritation of the tail evidence was obtained to the effect that substances both lowering the serotonin content in the brain (p-chlorphenylalanine, reserpine) and raising it (5-oxytryptophan, pargilin) cause a fall of the threshold, viz. 5-oxytryptophan and pargilin display antagonism to the analgetic effect of trimeperidine hydrochloride, whereas p-chlorphenylalanine, and inhibitor of trypophan-hydroxylase and tipindol, an antagonist of serotonin, do not exert any noticeable influence on the extent of the analgesic effect of trimeperidine hydrochloride.

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