Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Apr 1;143(4):999-1004.
doi: 10.1084/jem.143.4.999.

Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells

K Pfizenmaier, A Strazinski-Powitz, H Rodt, M Röllinghoff, H Wagner

Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells

K Pfizenmaier et al. J Exp Med. .

Abstract

Immune spleen cells from LCM virus-infected (CBA X C57BL/6)F1 radiation chimeras entirely repopulated with CBA-T6 lymphocytes were cytotoxic for allogeneic, LCM virus infected C57BL/6 mouse-derived target cells. Normal C57BL/6 targets were not lysed. CBA-T6 lymphocytes derived from (CBA X C57BL/6) radiation chimeras sensitized in vitro against TNP-conjugated C57BL/6 spleen cells lysed TNP-conjugated C57BL/6 targets. However normal C57BL/6 mouse-derived targets were not destroyed. The magnitude of virus-specific (or TNP-specific) cytotoxic responses against H-2 incompatible targets was lower compared to that against H-2 compatible targets. These data are considered to support and to extend the altered self concept, but are not consistent with the dual recognition concept.

PubMed Disclaimer

References

    1. Eur J Immunol. 1975 Apr;5(4):245-51 - PubMed
    1. Eur J Immunol. 1974 May;4(5):378-87 - PubMed
    1. J Exp Med. 1975 Dec 1;142(6):1477-87 - PubMed
    1. J Exp Med. 1975 Jun 1;141(6):1427-36 - PubMed
    1. Nature. 1974 Oct 11;251(5475):547-8 - PubMed