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Review
. 2000 May 18;405(6784):299-304.
doi: 10.1038/35012500.

Lateral gene transfer and the nature of bacterial innovation

H Ochman  1 , J G Lawrence, E A Groisman
Affiliations
Review

Lateral gene transfer and the nature of bacterial innovation

H Ochman et al. Nature. .

Abstract

Unlike eukaryotes, which evolve principally through the modification of existing genetic information, bacteria have obtained a significant proportion of their genetic diversity through the acquisition of sequences from distantly related organisms. Horizontal gene transfer produces extremely dynamic genomes in which substantial amounts of DNA are introduced into and deleted from the chromosome. These lateral transfers have effectively changed the ecological and pathogenic character of bacterial species.

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