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. 2000 Jun;66(6):2664-7.
doi: 10.1128/AEM.66.6.2664-2667.2000.

Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus

I A Parshikov  1 , J P Freeman, J O Lay Jr, R D Beger, A J Williams, J B Sutherland
Affiliations

Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus

I A Parshikov et al. Appl Environ Microbiol. 2000 Jun.

Abstract

Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N-oxide (62% of the total absorbance), N-acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%).

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Figures

FIG. 1
FIG. 1
HPLC chromatogram, obtained at 280 nm, for the metabolites (I to III) produced from enrofloxacin by M. ramannianus.
FIG. 2
FIG. 2
Structures of enrofloxacin (A) and metabolites formed during the transformation of enrofloxacin by M. ramannianus (B through D) (B) Desethylene-enrofloxacin; (C) enrofloxacin N-oxide; (D) N-acetylciprofloxacin.
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References

    1. Azerad R. Microbial models for drug metabolism. Adv Biochem Eng Biotechnol. 1999;63:169–218. - PubMed
    1. Barrow P A, Lovell M A, Szmolleny G, Murphy C K. Effect of enrofloxacin administration on excretion of Salmonella enteritidis by experimentally infected chickens and on quinolone resistance of their Escherichia coli flora. Avian Pathol. 1998;27:586–590. - PubMed
    1. Borner K, Borner E, Hartwig H, Lode H. HPLC of recent quinolone antimicrobials. In: Reid E, Wilson I D, editors. Analysis for drugs and metabolites, including anti-infective agents. Cambridge, England: Royal Society of Chemistry; 1990. pp. 131–144.
    1. Brown S A. Fluoroquinolones in animal health. J Vet Pharmacol Ther. 1996;19:1–14. - PubMed
    1. Cerniglia C E, Hansen E B, Jr, Lambert K J, Korfmacher W A, Miller D W. Fungal transformations of antihistamines: metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives. Xenobiotica. 1988;18:301–312. - PubMed

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