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Review
. 2000 May;35(3):317-29.
doi: 10.1016/s0531-5565(00)00083-8.

Tumor suppressors and oncogenes in cellular senescence

F Bringold  1 , M Serrano
Affiliations
Review

Tumor suppressors and oncogenes in cellular senescence

F Bringold et al. Exp Gerontol. 2000 May.

Abstract

Cyclin-dependent kinase inhibitors p16(INK4a), p21(Cip1), and p27(Kip1) are regarded as key effectors of cellular senescence. In this review, we describe three senescence-inducing pathways involving these inhibitors, namely, the p16(INK4a)/Rb pathway, the p19(ARF)/p53/p21(Cip1) pathway, and the PTEN/p27(Kip1) pathway. We emphasize the participation of tumor suppressors and oncogenes in the regulation of these senescence-inducing pathways. Finally, we discuss the impact of the Ras and Myc oncogenes on the above-mentioned pathways.

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