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. 1976 May;57(5):1386-90.
doi: 10.1172/JCI108407.

Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia

F Ciccimarra, F S Rosen, E Schneeberger, E Merler

Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia

F Ciccimarra et al. J Clin Invest. 1976 May.

Abstract

Four patients with common, variable agammaglobulinemia were preveiously reported to have normal numbers of circulating B lymphocytes which synthesized normal amounts of IgG in tissue culture but failed to secrete the newly synthesized IgG. The B lymphocytes of these patients fail to incorporate [3H]mannose and/or [3H]glucosamine into newly synthesized IgG, whereas such incorporation appears to occur just before IgG secretion in cultures of normal B lymphocytes.

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