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. 1976 May 1;143(5):1265-70.
doi: 10.1084/jem.143.5.1265.

Growth of B-lymphocytes clones in semisolid culture is mitogen dependent

P W Kincade, P Ralph, M A Moore

Growth of B-lymphocytes clones in semisolid culture is mitogen dependent

P W Kincade et al. J Exp Med. .

Abstract

A substance which was mitogenic for murine B lymphocytes in the presence of 2-mercaptoethanol was isolated from agar. Stimulating activity of this material was stable to proteolysis or protein denaturants but was destroyed by periodate treatment. Agar-derived mitogen stimulation was distinct from that obtained with dextran sulfate or lipopolysaccharide and may define different populations of B lymphocytes.

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References

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