Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Dec;14(6):517-38.

Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT)

I Niculescu-Duvaz  1 , F Friedlos, D Niculescu-Duvaz, L Davies, C J Springer
Affiliations
  • PMID: 10834273
Review

Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT)

I Niculescu-Duvaz et al. Anticancer Drug Des. 1999 Dec.

Abstract

Antibody- and gene-directed enzyme prodrug therapy are two-step targeting strategies designed to improve the selectivity of antitumour agents. The approaches are based on the activation of specially designed prodrugs by antibody-enzyme conjugates targeted to tumour-associated antigens (ADEPT) or by enzymes expressed by exogenous genes in tumour cells (GDEPT). Herein the design, synthesis, physico-chemical and biological properties, kinetics and clinical trials of the prodrugs and the enzymes carboxypeptidase G2 and nitroreductase are reviewed for ADEPT and GDEPT.

PubMed Disclaimer

Publication types

LinkOut - more resources