[C-reactive protein]

Abstract

C-reactive protein (CRP) is a reliable biochemical marker for tissue destruction, necrosis and inflammation. CRP is an essential human acute phase reactant produced in the liver as response to systemic stimuli. The biological half-life of CRP is not influenced by age, liver- or kidney function or pharmacotherapy. CRP values in acute bacterial infections have been appreciated for 70 years. The new standardized CRP analyses yield the possibilities of longitudinal monitoring of chronic inflammatory diseases and help identify complications. The more sensitive measures of the area of reference also supplies new information: As a prognostic marker for microvasculitis, CRP is at present re-writing the agenda for today's research in inflammation, angina pectoris, vascular insults and atherosclerosis.